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DigoxinTDM Calculator

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Patient demographic and lab value
Diagnosis

Is patient diagnosed with congestive heart failure (CHF)?

Concomitant drug

Does patient currently on Quinidine, Amiodarone or Verapramil?

System will automatically apply:

Clearance correction of

Volume of distribution correction factor of

Thyroid function status

System will automatically apply:

Clearance correction of

Volume of distribution correction factor of

Both concomitact drug and thyroid function will affect clearance and volume of distribution.

System will include both correction factors (for concomitant drug and abnormal thyroid function) into calculation.

If you wish to use only one correction factor, kindly switch one of the field to "none" (for concomitant drug) or "normal" for thyroid function.

Serum potassium status

Hypokalemia will increase digoxin distribution to myocardium.

Hyperkalemia will decrease digoxin distribution to myocardium.

Serum sodium status

Hyponatremia will decrease digoxin distribution to myocardium.

Hypernatremia

Target level

Target range

CHF: 0.5 - 0.9 mcg/L

AF: 0.8 - 2 mcg/L

Calculation completed

Estimated Digoxin Clearance (L/hour):

 

Estimated Vd (L):

 

Creatinine clearance (mL/min):

 

Get the expected digoxin level

Enter values below to calculate expected digoxin level for this patient

Planned regimen
Expected level (mcg/L):

 

Toxic level?

No problem. Enter values below to calculate dose of Digoxin Immune Fab

Current situation

Patient's body weight:

Suggested dose of Digoxin Immune Fab: IV 800 mg

~start with 400 mg IV, observe response; repeat with remaining 400 mg IV as needed

Assuming each vial of Digoxin Immune Fab is 40 mg

Suggested dose of Digoxin Immune Fab (in vials): vials

*each vial of DigiFab 40 mg will bind 0.5 mg of digoxin

Suggested dose of Digoxin Immune Fab: IV 240 mg

OR

Suggested dose of Digoxin Immune Fab (in vials): vials