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AminoglycosideTDM Calculator

   

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Measured levels
Patient demographic and lab value Lab data

Patient is Adult.

Vd range: 0.2 - 0.3 L/kg

System is using: 0.25 L/kg

Patient is obese.

Total body weight >30% of IBW.

Vd = 0.26 [IBW + 0.4 (TBW – IBW)] = L

Vd value for cystic fibrosis = 0.35 L/kg

System is using: 0.35 L/kg

Target levels
Current regimen
Infusion details
Sampling details
Alpha distribution

Some pharmacists may prefer to add alpha distribution phase (typically 0.5 hour).

By default, system is not including alpha distribution, as we always assume infusion duration of 1 hour is sufficient for the drug to distribute to whole body.

If you wish to add alpha distribution, kindly change the value below (default is 0 hour)

Calculation completed

Initial dose (unrounded):

 

Initial interval (unrounded):

 

Initial dose (rounded to 250mg):

 

Initial interval (rounded):

 

Estimated Cmax (mg/L):

 

Estimated Cmin (mg/L):

 

Estimated t1/2 (hr):

 

Estimated Vd (L):

 

Estimated Ke (hr-1):

 

tMIC with MIC = 0.5mg/L

 

DFP (hr): with MIC = 0.5mg/L

 

Fine tune patient's regimen Don't like the expected Cmax and Cmin above?

Enter values below to calculate expected pharmacokinetics parameters Enter your own dose and frequency to see the new expected Cmax and Cmin

Planned regimen
Expected Cmax (mg/L):

 

Expected Cmin (mg/L):

 

DFP (hour):

 

Toxic level?

No problem. Enter values below to calculate duration to withhold

Current situation
Duration to withhold:

 

Expected time to achieve target level:

*assuming Cmax occured on today at